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Literature summary for 3.1.6.2 extracted from

  • Purohit, A.; Potter, B.V.; Parker, M.G.; Reed, M.J.
    Steroid sulphatase: expression, isolation and inhibition for active-site identification studies (1998), Chem. Biol. Interact., 109, 183-193.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli and CHO cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
estrone-3-O-sulfamate active site-directed inhibitor; EMATE, most potent, irreversible Helix pomatia
estrone-3-O-sulfamate active site-directed inhibitor; EMATE, most potent, irreversible Homo sapiens
Rose bengal histidine modification Helix pomatia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
steroid sulfates + H2O Homo sapiens also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
?
steroid sulfates + H2O Helix pomatia also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site steroid + sulfate
-
?

Organism

Organism UniProt Comment Textmining
Helix pomatia
-
-
-
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
Homo sapiens
glycoprotein is glycosylated, binds to concanavalin A Helix pomatia

Purification (Commentary)

Purification (Comment) Organism
of the recombinant protein Homo sapiens
partial, the soluble enzyme Helix pomatia

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone 3-sulfate + H2O
-
Homo sapiens dehydroepiandrosterone + sulfate
-
?
dehydroepiandrosterone 3-sulfate + H2O
-
Helix pomatia dehydroepiandrosterone + sulfate
-
?
estrone sulfate + H2O
-
Homo sapiens estrone + sulfate
-
?
estrone sulfate + H2O
-
Helix pomatia estrone + sulfate
-
?
steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Homo sapiens steroid + sulfate
-
?
steroid sulfates + H2O also acts on some related steryl sulfates, phenol sulfates, steroid arylsulfates and steroid alkyl sulfates catalyzed at the same site Helix pomatia steroid + sulfate
-
?