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Literature summary for 3.1.6.13 extracted from

  • Archer, I.M.; Harper, P.S.; Wusteman, F.S.
    Multiple forms of iduronate 2-sulphate sulphatase in human tissues and body fluids (1982), Biochim. Biophys. Acta, 708, 134-140.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
NaCl due to Cl- Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
95000
-
form A, B, gel filtration Homo sapiens
132000
-
form C, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dermatan sulfate + H2O Homo sapiens
-
dermatan + sulfate
-
?
heparan sulfate + H2O Homo sapiens
-
dermatan + sulfate
-
?
heparin + H2O Homo sapiens
-
desulfated heparin + sulfate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
multiple forms: A, B, C
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein contains sialic acid residues Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
amniotic fluid
-
Homo sapiens
-
kidney contains only form A Homo sapiens
-
placenta
-
Homo sapiens
-
serum distribution of the forms A, B and C in body fluids Homo sapiens
-
serum contains only form C Homo sapiens
-
urine
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dermatan sulfate + H2O
-
Homo sapiens dermatan + sulfate
-
?
heparan sulfate + H2O
-
Homo sapiens dermatan + sulfate
-
?
heparin + H2O
-
Homo sapiens desulfated heparin + sulfate
-
?
O-(alpha-L-idopyranosyluronic acid 2-sulfate)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + H2O
-
Homo sapiens O-(alpha-L-idopyranosyluronic acid)-(1-4)-2,5-anhydro-D-mannitol 6-sulfate + sulfate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1 5.3 form C, depending on ionic strength Homo sapiens
4.4 5.3 form B, depending on ionic strength Homo sapiens
4.5 5.3 form A, depending on ionic strength Homo sapiens