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Literature summary for 3.1.5.B1 extracted from
- Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592 (2015), J. Biol. Chem., 290, 26352-26359 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| structures of variants T592E and T592V. Mutation T592E induces large conformational changes, likely triggered by electrostatic repulsion from a distinct negatively charged environment surrounding residue Thr-592 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| T592E | phosphomimetic mutation, reduces the stability of the SAMHD1 tetramer. about 3fold decrease in activity | Homo sapiens |
| T592V | neutral substitution, does not perturb the structure | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y3Z3 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dATP + H2O | - |
Homo sapiens | deoxyadenosine + triphosphate | - |
? |  |
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Release 2023.1 (January 2023)
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