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Literature summary for 3.1.4.60 extracted from

  • Bowman, L.; Zeden, M.S.; Schuster, C.F.; Kaever, V.; Gruendling, A.
    New insights into the cyclic di-adenosine monophosphate (c-di-AMP) degradation pathway and the requirement of the cyclic dinucleotide for acid stress resistance in Staphylococcus aureus (2016), J. Biol. Chem., 291, 26970-26986 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.60

Inhibitors

Inhibitors Comment Organism Structure
ppGpp
-
 Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O Staphylococcus aureus
-
 2 AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A0A0H2XFX6 USA300
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-O-phosphonoadenylyl-(3'->5')-adenosine + H2O
-
 Staphylococcus aureus 2 AMP
-
 ?
additional information Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP Staphylococcus aureus ?
-
 ?
additional information Pde2 is capable of hydrolyzing c-di-AMP, but5 preferentially converts linear 5'-phosphadenylyl-adenosine (pApA) to AMP. No substrate: ATP Staphylococcus aureus USA300 ?
-
 ?

Synonyms

Synonyms Comment Organism
SAUSA300_1650
-
 Staphylococcus aureus

General Information

General Information Comment Organism
physiological function a Pde2 mutant strain displays a growth defect in the early growth phase. The mutant displays an increase in cellular c-di-AMP and 5'-O-phosphonoadenylyl-(3'->5')-adenosine levels and increased oxacillin resistance. A strain producing a high level of c-di-AMP has increased and a stain producing low levels has decreased acid resistance Staphylococcus aureus