Literature summary for 3.1.4.54 extracted from

Zhu, C.; Solorzano, C.; Sahar, S.; Realini, N.; Fung, E.; Sassone-Corsi, P.; Piomelli, D.
Proinflammatory stimuli control NAPE-PLD expression in macrophages (2011), Mol. Pharmacol., 79, 786-792.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8BH82	-	-

Synonyms

Synonyms	Comment	Organism
N-acylphosphatidylethanolamine-specific phospholipase D	-	Mus musculus
NAPE-PLD	-	Mus musculus

Expression

Organism	Comment	Expression
Mus musculus	the pro-inflammatory bacterial endotoxin, lipopolysaccharide, decreases palmitoylethanolamide biosynthesis in RAW264.7 macrophages by suppressing the transcription of NAPE-PLD, which catalyzes the production of palmitoylethanolamide and other lipid amides. Liopolysaccharide treatment reduces acetylation of histone proteins bound to the NAPE-PLD promoter, an effect that is blocked by the histone deacetylase inhibitor richostatin A. The transcription factor Sp1 is involved in regulating baseline NAPE-PLD expression, but not in the transcriptional suppression induced by lipopolysaccharide. The down-regulation of NAPE-PLD expression may be functionally important because mutant NAPE-PLD-null mice, in which this regulatory process is defective, are unable to mount a normal inflammatory reaction in response to carrageenan	down

General Information

General Information	Comment	Organism
physiological function	the down-regulation of NAPE-PLD expression may be functionally important because mutant NAPE-PLD-null mice, in which this regulatory process is defective, are unable to mount a normal inflammatory reaction in response to carrageenan	Mus musculus

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Release 2023.1 (January 2023)