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Literature summary for 3.1.4.54 extracted from

  • Egertova, M.; Simon, G.M.; Cravatt, B.F.; Elphick, M.R.
    Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules (2008), J. Comp. Neurol., 506, 604-615.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acylphosphatidylethanolamine + H2O Mus musculus the enzyme is involved in formation of N-acylethanolamines, membrane-derived lipids that are utilized as signaling molecules in the nervous system (e.g., the endocannabinoid anandamide) N-acylethanolamine + phosphatidate
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8BH82
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Source Tissue

Source Tissue Comment Organism Textmining
brain NAPE-PLD is expressed by specific populations of neurons in the brain and targeted to axonal processes. In the dentate gyrus a strong mRNA signal is detected in granule cells. Immunocytochemical analysis reveales intense NAPE-PLD immunoreactivity in the axons of granule cells (mossy fibers) and in axons of the vomeronasal nerve that project to the accessory olfactory bulb. NAPE-PLD expression is detected in hippocampus, cortex, thalamus, hypothalamus, but the intensity of immunostaining is weaker than in mossy fibers Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acylphosphatidylethanolamine + H2O the enzyme is involved in formation of N-acylethanolamines, membrane-derived lipids that are utilized as signaling molecules in the nervous system (e.g., the endocannabinoid anandamide) Mus musculus N-acylethanolamine + phosphatidate
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Synonyms

Synonyms Comment Organism
NAPE-PLD
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 Mus musculus

General Information

General Information Comment Organism
malfunction NAPE-PLD -/- mice have greatly reduced brain levels of long-chain saturated N-acylethanolamines but wild-type levels of polyunsaturated N-acylethanolamines (e.g., anandamide), suggesting an important role for NAPE-PLD in the biosynthesis of at least a subset of endogenous NAEs in the mammalian nervous system Mus musculus
physiological function the enzyme is involved in formation of N-acylethanolamines, membrane-derived lipids that are utilized as signaling molecules in the nervous system (e.g., the endocannabinoid anandamide). N-acylethanolamines generated by NAPE-PLD in axons may act as anterograde synaptic signaling molecules that regulate the activity of postsynaptic neurons Mus musculus