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Literature summary for 3.1.4.53 extracted from

  • Korkmaz, S.; Maupoil, V.; Sobry, C.; Brunet, C.; Chevalier, S.; Freslon, J.L.
    An increased regional blood flow precedes mesenteric inflammation in rats treated by a phosphodiesterase 4 inhibitor (2009), Toxicol. Sci., 107, 298-305.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
CI-1044 i.e. (R)-N-[9-amino-3,4,6,7-tetrahydro-4-oxo-1-phenylpyrrolo[3,2,1-j,k][1,4] benzodiazepin-3-yl]-3-pyridinecarboxamide, selective inhibitor of PDE4, administration of 160 mg/kg of CI-1044 causes perivascular and interstitial inflammation, with infiltrates of admixed neutrophils and macrophages but without evidence of vascular necrosis, PDE4 inhibitor CI-1044 induces changes of vascular tone that could lead to histological alterations in the mesenteric area Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
PDE4
-
Rattus norvegicus
phosphodiesterase 4
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0005
-
pH and temperature not specified in the publication Rattus norvegicus CI-1044