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Literature summary for 3.1.4.53 extracted from

  • Cashman, J.R.; Voelker, T.; Zhang, H.T.; ODonnell, J.M.
    Dual inhibitors of phosphodiesterase-4 and serotonin reuptake (2009), J. Med. Chem., 52, 1530-1539.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.53

Inhibitors

Inhibitors Comment Organism Structure
4-(3,4-dimethoxy-phenyl)-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one PDE4 inhibitor, potent inhibitor of isoform PDE4D3 Mus musculus
4-(3,4-dimethoxyphenyl)-2-{5-[(2-{5-[2-(2-fluoro-5-methoxyphenyl)ethyl]tetrahydrofuran-2-yl}ethyl)amino]pentyl}-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one the dual PDE4 inhibitor/selective serotonin reuptake inhibitor shows potent and selective serotonin reuptake inhibition Mus musculus
rolipram PDE4 inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3',5'-cAMP + H2O Mus musculus
-
 5'-AMP
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE4
-
 Mus musculus
PDE4D3 isoform Mus musculus
phosphodiesterase-4
-
 Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000002
-
 4-(3,4-dimethoxyphenyl)-2-{5-[(2-{5-[2-(2-fluoro-5-methoxyphenyl)ethyl]tetrahydrofuran-2-yl}ethyl)amino]pentyl}-4a,5,8,8a-tetrahydrophthalazin-1(2H)-one isoform PDE4D3, pH and temperature not specified in the publication Mus musculus