Literature summary for 3.1.4.53 extracted from

van Donkelaar, E.L.; Rutten, K.; Blokland, A.; Akkerman, S.; Steinbusch, H.W.; Prickaerts, J.
Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion (2008), Eur. J. Pharmacol., 600, 98-104.

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Application

Application	Comment	Organism
medicine	PDE5 inhibition improved short-term object recognition performance after an acute tryptophan depletion induced deficit	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
vardenafil	PDE5 inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3',5'-cAMP + H2O	-	Rattus norvegicus	5'-AMP	-	?

Synonyms

Synonyms	Comment	Organism
PDE5	-	Rattus norvegicus
phosphodiesterase 5	-	Rattus norvegicus

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Release 2023.1 (January 2023)