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Literature summary for 3.1.4.53 extracted from

  • Santos-Silva, A.J.; Cairrao, E.; Morgado, M.; Alvarez, E.; Verde, I.
    PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries (2008), Eur. J. Pharmacol., 582, 102-109.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
rolipram PDE4 is specifically inhibited by rolipram; PDE4 is specifically inhibited by rolipram; PDE4 is specifically inhibited by rolipram; PDE4 is specifically inhibited by rolipram Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27815 PDE4A
-
Homo sapiens Q07343 PDE4B
-
Homo sapiens Q08493 PDE4C
-
Homo sapiens Q08499 PDE4D
-
Homo sapiens Q13946 PDE7A
-
Homo sapiens Q13946 PDE7A2
-

Source Tissue

Source Tissue Comment Organism Textmining
umbilical artery smooth muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3',5'-cAMP + H2O specific substrate Homo sapiens 5'-AMP
-
 ?
3',5'-cAMP + H2O PDE4 hydrolyses selectively 3',5'-cAMP with high affinity Homo sapiens 5'-AMP
-
 ?

Synonyms

Synonyms Comment Organism
PDE4 key enzyme involved in the regulation of the smooth muscle relaxation associated to cAMP Homo sapiens
PDE4A isoform Homo sapiens
PDE4B isoform Homo sapiens
PDE4C isoform Homo sapiens
PDE4D isoform Homo sapiens
PDE7
-
 Homo sapiens
PDE7A isoform Homo sapiens
PDE7A2 isoform Homo sapiens