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Literature summary for 3.1.4.53 extracted from
- Real-time monitoring of phosphodiesterase inhibition in intact cells (2008), Cell. Signal., 20, 1423-1431.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Epac1-camps-PDE4A1 fusion protein is expressed in HEK-293 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-isobuytl-1-methylxanthine | - |
Homo sapiens |  |
| Ro20-1724 | PDE4 inhibitor | Homo sapiens | |
| rolipram | PDE4 inhibitor | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27815 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',5'-cAMP + H2O | - |
Homo sapiens | 5'-AMP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PDE4 | - |
Homo sapiens |
| PDE4A1 | isoform | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000021 | - |
- |
Homo sapiens | rolipram | |
| 0.000042 | - |
- |
Homo sapiens | Ro20-1724 | |
| 0.0059 | - |
- |
Homo sapiens | 3-isobuytl-1-methylxanthine | |
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Release 2023.1 (January 2023)
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