Cloned (Comment) | Organism |
---|---|
PDE7B protein is expressed in a baculovirus expression system | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-isobutyl-1-methylxanthine | - |
Mus musculus | |
dipyridamole | - |
Mus musculus | |
erythro-9-[3-(2-hydroxynonyl)]-adenine | - |
Mus musculus | |
papaverine | - |
Mus musculus | |
rolipram | - |
Mus musculus | |
SCH51866 | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00003 | - |
adenosine 3',5'-cyclic phosphate | - |
Mus musculus | |
0.0001 | - |
adenosine 3',5'-cyclic phosphate | PDE7A2 | Mus musculus | |
0.0002 | - |
adenosine 3',5'-cyclic phosphate | PDE7A1 | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
x * 50000, PDE7A2, calculated from sequence | Mus musculus |
50100 | - |
x * 50100, calculated from sequence | Mus musculus |
57000 | - |
x * 57000, PDE7A1, calculated from sequence | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P70453 | - |
- |
Mus musculus | Q9QXQ1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | PDE7A1 | Mus musculus | - |
epididymis | - |
Mus musculus | - |
eye | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
heart | PDE7A2 | Mus musculus | - |
kidney | PDE7A1 | Mus musculus | - |
liver | - |
Mus musculus | - |
lung | PDE7A1 | Mus musculus | - |
lymphoid tissue | PDE7A1 | Mus musculus | - |
ovary | - |
Mus musculus | - |
pancreas | most highly expressed in pancreas followed by brain, heart, thyroid, skeletal muscle, eye, ovary, submaxillary gland, epididymus, and liver | Mus musculus | - |
pancreas | PDE7A1 | Mus musculus | - |
placenta | PDE7A1 | Mus musculus | - |
skeletal muscle | - |
Mus musculus | - |
skeletal muscle | PDE7A2 | Mus musculus | - |
submandibular gland | - |
Mus musculus | - |
thyroid gland | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenosine 3',5'-cyclic phosphate + H2O | no activity with cGMP | Mus musculus | adenosine 5'-phosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 50000, PDE7A2, calculated from sequence | Mus musculus |
? | x * 50100, calculated from sequence | Mus musculus |
? | x * 57000, PDE7A1, calculated from sequence | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
PDE7B | - |
Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0021 | - |
- |
Mus musculus | 3-isobutyl-1-methylxanthine | |
0.0045 | - |
- |
Mus musculus | 3-isobutyl-1-methylxanthine | |
0.009 | - |
- |
Mus musculus | dipyridamole | |
0.0125 | - |
- |
Mus musculus | papaverine | |
0.022 | - |
- |
Mus musculus | papaverine | |
0.035 | - |
- |
Mus musculus | SCH51866 | |
0.042 | - |
- |
Mus musculus | dipyridamole | |
0.044 | - |
- |
Mus musculus | SCH51866 | |
0.13 | - |
- |
Mus musculus | erythro-9-[3-(2-hydroxynonyl)]-adenine | |
0.18 | - |
- |
Mus musculus | rolipram |