Application | Comment | Organism |
---|---|---|
medicine | reactive oxygen-species mediated lung inflammation may be mediated at least in part by calcium and elevated enzyme activity associated with decreased caMP in both macorphages and epithelial cells | Mus musculus |
medicine | reactive oxygen-species mediated lung inflammation may be mediated at least in part by calcium and elevated enzyme activity associated with decreased caMP in both macorphages and epithelial cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment with oxidant t-butylhydroperoxide results in release of significant amounts of interleukin-8, which is prevented by inhibition of enzyme isoforms PDE1 and PDE4 | Homo sapiens | |
additional information | the oxidant t-butylhydroperoxide signifcantly increases the cytosolic calcium concentration. Inhibition of both isoforms PDE1 and PDE4 completely prevent the t-butylhydroperoxide stimulated TNF-alpha release | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform PDE4 | - |
Mus musculus | - |
isoform PDE4 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | lung epithelial cell | Homo sapiens | - |
J-774 cell | macrophage cell | Mus musculus | - |