Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.1.4.53 extracted from

  • Narita, M.; Murata, T.; Shimizu, K.; Nakagawa, T.; Sugiyama, T.; Inui, M.; Hiramoto, K.; Tagawa, T.
    A role for cyclic nucleotide phosphodiesterase 4 in regulation of the growth of human malignant melanoma cells (2007), Oncol. Rep., 17, 1133-1139.
    View publication on PubMed
Search for more literature for 3.1.4.53

Application

Application Comment Organism
medicine enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Ro-20-1724 inhibition of PDE4, resulting in increased intacelular cAMP Homo sapiens
rolipram inhibition of PDE4, resulting in increased intacelular cAMP Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform PDE4
-

Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell line gingiva-derived malignant melanoma cell, expression of variants PDE4B and PDE4D Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme variants PDE4B and/or PDE4D regulate cell growth through cAMP targets in the HMG malignant melanoma cell Homo sapiens ?
-
 ?