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Literature summary for 3.1.4.53 extracted from
- The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10 (2007), J. Mol. Biol., 371, 302-307.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the catalytic domain in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| catalytic domain of inactive mutant D201N in complex with substrate cAMP at 1.56 A resolution. Q369 forms only one hydrogen bond ith the adenine of cAMP. Structural comparison between isoform PDE4D2-cAMP and PDE10A2-cAMP shows an anti configuration of cAMP in PDE4, but syn in PDE10 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isoform PDE4D2 | - |
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Release 2023.1 (January 2023)
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