Cloned (Comment) | Organism |
---|---|
expression in COS-7 cell | Homo sapiens |
When expressed in COS-7 cells, PDE4A8 localizes predominantly in the cytosol, but 20% of the enzyme was associated with membrane fractions | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cilomilast | - |
Homo sapiens | |
rolipram | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | predominant localization, recombinant protein expressed in COS-7 cell | Homo sapiens | 5829 | - |
cytosol | when expressed in COS-7 cells, PDE4A8 localizes predominantly in the cytosol, but 20% of the enzyme is associated with membrane fractions | Homo sapiens | 5829 | - |
membrane | about 20% of protein is associated with membrane, recombinant protein expressed in COS-7 cell | Homo sapiens | 16020 | - |
membrane | when expressed in COS-7 cells, PDE4A8 localizes predominantly in the cytosol, but 20% of the enzyme is associated with membrane fractions | Homo sapiens | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
125000 | - |
x * 125000, SDS-PAGE, recombinant protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27815 | - |
- |
Homo sapiens | P27815 | isoform PDE4A8 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation of enzyme by cAMP-dependent protein kinase at S123 | Homo sapiens |
phosphoprotein | phosphorylation by cAMP-dependent protein kinase | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | and skeletal muscle, predominant expression | Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
cerebral cortex | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
skeletal muscle | and brain, predominant expression | Homo sapiens | - |
spinal cord | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 125000, SDS-PAGE, recombinant protein | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
PDE4A8 | - |
Homo sapiens |
phosphodiesterase 4 isoform A8 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000011 | - |
- |
Homo sapiens | rolipram | |
0.000101 | - |
- |
Homo sapiens | cilomilast |