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Literature summary for 3.1.4.53 extracted from

  • Jagadeesh, S.; Padma, T.; Parimala, H.; Chandramouli, K.H.; DSouza, C.J.; Thimmaiah, K.N.
    Inhibition of calmodulin-dependent cyclic AMP phosphodiesterase by phenoxazines (2006), Biochem. Biophys. Res. Commun., 342, 690-701.
    View publication on PubMed
Search for more literature for 3.1.4.53

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin required, Km value 0.000057 mM Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
10-(3-pyrrolidin-1-ylpropyl)-2-(trifluoromethyl)-10H-phenoxazine
-
 Bos taurus
10-(4'-N-morpholinobutyl)-2-chlorophenoxazine
-
 Bos taurus
10-(4'-N-morpholinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
10-(4'-N-piperidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
10-(4'-N-piperidinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
10-(4'-N-pyrrolidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine increase of Km value in presence of inhibitor Bos taurus
10-[3'-[(beta-hydroxyethyl)-piperazino]propyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
10-[30-[(beta-hydroxy ethyl)-piperazino]propyl]-2-chlorophenoxazine
-
 Bos taurus
10-[4'-(N-diethylamino)-butyl]-2-chlorophenoxazine
-
 Bos taurus
10-[4'-(N-diethylamino)butyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
10-[4'-[(beta-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine
-
 Bos taurus
10-[4'-[(beta-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine
-
 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 calmodulin-dependent cAMP-phosphodiesterase, commercial product
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00018
-
 10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
0.00038
-
 10-[4'-[(beta-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine
-
 Bos taurus
0.00054
-
 10-(4'-N-piperidinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
0.00055
-
 10-[4'-[(beta-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine
-
 Bos taurus
0.00058
-
 10-(4'-N-pyrrolidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
0.0006
-
 10-[4'-(N-diethylamino)butyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
0.0007
-
 10-(4'-N-piperidinobutyl)-2-chlorophenoxazine
-
 Bos taurus
0.0008
-
 10-(4'-N-morpholinobutyl)-2-chlorophenoxazine
-
 Bos taurus
0.00087
-
 10-[30-[(beta-hydroxy ethyl)-piperazino]propyl]-2-chlorophenoxazine
-
 Bos taurus
0.00097
-
 10-[3'-[(beta-hydroxyethyl)-piperazino]propyl]-2-trifluoromethylphenoxazine
-
 Bos taurus
0.001
-
 10-(3-pyrrolidin-1-ylpropyl)-2-(trifluoromethyl)-10H-phenoxazine pH 7.5, 30°C Bos taurus
0.00101
-
 10-(4'-N-morpholinobutyl)-2-trifluoromethylphenoxazine
-
 Bos taurus
0.00105
-
 10-[4'-(N-diethylamino)-butyl]-2-chlorophenoxazine
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0023
-
-
 Bos taurus 10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine
0.0031
-
-
 Bos taurus 10-[4'-[(b-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine
0.0044
-
-
 Bos taurus 10-[4'-[(b-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine