Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | required, Km value 0.000057 mM | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
10-(3-pyrrolidin-1-ylpropyl)-2-(trifluoromethyl)-10H-phenoxazine | - |
Bos taurus | |
10-(4'-N-morpholinobutyl)-2-chlorophenoxazine | - |
Bos taurus | |
10-(4'-N-morpholinobutyl)-2-trifluoromethylphenoxazine | - |
Bos taurus | |
10-(4'-N-piperidinobutyl)-2-chlorophenoxazine | - |
Bos taurus | |
10-(4'-N-piperidinobutyl)-2-trifluoromethylphenoxazine | - |
Bos taurus | |
10-(4'-N-pyrrolidinobutyl)-2-chlorophenoxazine | - |
Bos taurus | |
10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine | increase of Km value in presence of inhibitor | Bos taurus | |
10-[3'-[(beta-hydroxyethyl)-piperazino]propyl]-2-trifluoromethylphenoxazine | - |
Bos taurus | |
10-[30-[(beta-hydroxy ethyl)-piperazino]propyl]-2-chlorophenoxazine | - |
Bos taurus | |
10-[4'-(N-diethylamino)-butyl]-2-chlorophenoxazine | - |
Bos taurus | |
10-[4'-(N-diethylamino)butyl]-2-trifluoromethylphenoxazine | - |
Bos taurus | |
10-[4'-[(beta-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine | - |
Bos taurus | |
10-[4'-[(beta-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine | - |
Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calmodulin-dependent cAMP-phosphodiesterase, commercial product | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00018 | - |
10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine | - |
Bos taurus | |
0.00038 | - |
10-[4'-[(beta-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine | - |
Bos taurus | |
0.00054 | - |
10-(4'-N-piperidinobutyl)-2-trifluoromethylphenoxazine | - |
Bos taurus | |
0.00055 | - |
10-[4'-[(beta-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine | - |
Bos taurus | |
0.00058 | - |
10-(4'-N-pyrrolidinobutyl)-2-chlorophenoxazine | - |
Bos taurus | |
0.0006 | - |
10-[4'-(N-diethylamino)butyl]-2-trifluoromethylphenoxazine | - |
Bos taurus | |
0.0007 | - |
10-(4'-N-piperidinobutyl)-2-chlorophenoxazine | - |
Bos taurus | |
0.0008 | - |
10-(4'-N-morpholinobutyl)-2-chlorophenoxazine | - |
Bos taurus | |
0.00087 | - |
10-[30-[(beta-hydroxy ethyl)-piperazino]propyl]-2-chlorophenoxazine | - |
Bos taurus | |
0.00097 | - |
10-[3'-[(beta-hydroxyethyl)-piperazino]propyl]-2-trifluoromethylphenoxazine | - |
Bos taurus | |
0.001 | - |
10-(3-pyrrolidin-1-ylpropyl)-2-(trifluoromethyl)-10H-phenoxazine | pH 7.5, 30°C | Bos taurus | |
0.00101 | - |
10-(4'-N-morpholinobutyl)-2-trifluoromethylphenoxazine | - |
Bos taurus | |
0.00105 | - |
10-[4'-(N-diethylamino)-butyl]-2-chlorophenoxazine | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0023 | - |
- |
Bos taurus | 10-(4'-N-pyrrolidinobutyl)-2-trifluoromethylphenoxazine | |
0.0031 | - |
- |
Bos taurus | 10-[4'-[(b-hydroxy ethyl)-piperazino]butyl]-2-trifluoro-methylphenoxazine | |
0.0044 | - |
- |
Bos taurus | 10-[4'-[(b-hydroxy-ethyl)piperazino]butyl]-2-chlorophenoxazine |