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Literature summary for 3.1.4.46 extracted from

  • Johnson, R.W.; McGillivary, G.; Denoel, P.; Poolman, J.; Bakaletz, L.O.
    Abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media (2011), Vaccine, 29, 1211-1221.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
generation of an 86-028NP-derived NTHI strain that expresses an hpd/glpQ promoter-driven luciferase reporter from the vector pKMLN-01, hpd/glpQ is expressed in an operon with glpT Haemophilus influenzae

Protein Variants

Protein Variants Comment Organism
additional information generation of a nonpolar hpd/glpQ mutant strain, that retains detectable mRNA expression of the upstream gene glpT, which is cotranscribed with hpd/glpQ Haemophilus influenzae

Localization

Localization Comment Organism GeneOntology No. Textmining
outer membrane
-
Haemophilus influenzae 19867
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alpha-glycerophosphocholine + H2O Haemophilus influenzae
-
choline + sn-glycerol-3-phosphate
-
?
L-alpha-glycerophosphocholine + H2O Haemophilus influenzae 86-028NP
-
choline + sn-glycerol-3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
nontypeable Haemophilus influenzae
-
Haemophilus influenzae 86-028NP
-
nontypeable Haemophilus influenzae
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein
-
Haemophilus influenzae

Source Tissue

Source Tissue Comment Organism Textmining
epithelial cell
-
Haemophilus influenzae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-alpha-glycerophosphocholine + H2O
-
Haemophilus influenzae choline + sn-glycerol-3-phosphate
-
?
L-alpha-glycerophosphocholine + H2O
-
Haemophilus influenzae 86-028NP choline + sn-glycerol-3-phosphate
-
?

Synonyms

Synonyms Comment Organism
PD/GlpQ
-
Haemophilus influenzae
Protein D
-
Haemophilus influenzae
protein D/glycerophosphodiester phosphodiesterase
-
Haemophilus influenzae

General Information

General Information Comment Organism
malfunction abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial A549 cells, and fitness in a chinchilla, Chinchilla lanigera, model of otitis media. Exposure of NTHI to antibodies directed against the vaccine formulation recapitulates the phosphorylcholine decoration and NTHI adherence phenotypes exhibite by PD/GlpQ-deficient NTHI, mechanism(s) of anti-PD/GlpQ antibody-mediated protection from NTHI-induced otitis media, overview Haemophilus influenzae
physiological function PD/GlpQ enzymatic activity is predicted to facilitate choline and sn-glycerol-3-phosphate acquisition via the cleavage of L-alpha-glycerophosphocholine, an abundant catabolite of host phospholipids Haemophilus influenzae