Literature summary for 3.1.4.41 extracted from

Vargas-Villarreal, J.; Palacios-Corona, R.; Hernandez-Luna, C.; Mata-Cardenas, B.D.; Torres de la Cruz, V.M.; Cortes-Gutierrez, E.I.; Gonzalez-Salazar, F.; Garza-Gonzalez, J.N.; Escobedo-Guajardo, B.L.; Said-Fernandez, S.
Entamoeba histolytica: soluble and membrane-associated neutral sphingomyelinase-C and other unidentified esterase activity (2010), Exp. Parasitol., 125, 394-399.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Ca2+	-	Entamoeba histolytica
EDTA	-	Entamoeba histolytica
Hg2+	-	Entamoeba histolytica
phosphatidylinositol-3,5-bisphosphate	-	Entamoeba histolytica
Zn2+	-	Entamoeba histolytica

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	associated, SMase-C activity is detected in soluble and particulate fractions	Entamoeba histolytica	16020	-
soluble	SMase-C activity is detected in soluble and particulate fractions	Entamoeba histolytica	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Co2+	dependent on divalent cations	Entamoeba histolytica
Mg2+	dependent on divalent cations	Entamoeba histolytica
Mn2+	dependent on divalent cations	Entamoeba histolytica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
sphingomyelin + H2O	Entamoeba histolytica	-	ceramide 1-phosphate + choline	-	?
sphingomyelin + H2O	Entamoeba histolytica HM1	-	ceramide 1-phosphate + choline	-	?

Organism

Organism	UniProt	Comment	Textmining
Entamoeba histolytica	-	-	-
Entamoeba histolytica HM1	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
trophozoite	-	Entamoeba histolytica	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
54.3	-	membrane-associated enzyme, pH 7.5, 36.5°C	Entamoeba histolytica
84.3	-	soluble enzyme, pH 7.5, 36.5°C	Entamoeba histolytica

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
sphingomyelin + H2O	-	Entamoeba histolytica	ceramide 1-phosphate + choline	-	?
sphingomyelin + H2O	-	Entamoeba histolytica HM1	ceramide 1-phosphate + choline	-	?

Synonyms

Synonyms	Comment	Organism
SMase	-	Entamoeba histolytica
SMase-C	-	Entamoeba histolytica
sphingomyelinase	-	Entamoeba histolytica

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
36.5	-	assay at	Entamoeba histolytica

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	-	Entamoeba histolytica

pH Range

pH Minimum	pH Maximum	Comment	Organism
3	10	activity range	Entamoeba histolytica

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Release 2023.1 (January 2023)