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Literature summary for 3.1.4.41 extracted from

  • Tambourgi, D.V.; Pedrosa, M.F.; de Andrade, R.M.; Billington, S.J.; Griffiths, M.; van den Berg, C.W.
    Sphingomyelinases D induce direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis (2007), Mol. Immunol., 44, 576-582.
    View publication on PubMed
Search for more literature for 3.1.4.41

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Corynebacterium pseudotuberculosis
expression in Escherichia coli Loxosceles intermedia

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ inhibits activity on phosphatidylcholine Corynebacterium pseudotuberculosis
Mg2+ inhibits activity on phosphatidylcholine Loxosceles intermedia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphingomyelin + H2O Loxosceles intermedia bites by Loxosceles spiders can induce severe clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, haemolysis and persistent inflammation. the causative toxin is sphingomyelinase D. Spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis choline + ceramide 1-phosphate
-
 ?
sphingomyelin + H2O Corynebacterium pseudotuberculosis spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis choline + ceramide 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Corynebacterium pseudotuberculosis
-
-
-
Corynebacterium pseudotuberculosis
-
 recombinant fusion protein composed of the mature PLD protein with a 33 amino acid N-terminal extension containing a 6His tag
-
Loxosceles intermedia
-
-
-
Loxosceles intermedia
-
 recombinant fusion protein with 36 amino acid N-terminal extension containing a 6His tag
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Loxosceles intermedia
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-lysophosphatidylcholine + H2O
-
 Corynebacterium pseudotuberculosis 2-lysophosphatidate + choline
-
 ?
2-lysophosphatidylcholine + H2O
-
 Loxosceles intermedia 2-lysophosphatidate + choline
-
 ?
phosphatidylcholine + H2O no activity in presence of Mg2+ Corynebacterium pseudotuberculosis phosphatidic acid + choline
-
 ?
phosphatidylcholine + H2O no activity in presence of Mg2+ Loxosceles intermedia phosphatidic acid + choline
-
 ?
sphingomyelin + H2O
-
 Corynebacterium pseudotuberculosis choline + ceramide 1-phosphate
-
 ?
sphingomyelin + H2O
-
 Loxosceles intermedia choline + ceramide 1-phosphate
-
 ?
sphingomyelin + H2O bites by Loxosceles spiders can induce severe clinical symptoms, including dermonecrosis, thrombosis, vascular leakage, haemolysis and persistent inflammation. the causative toxin is sphingomyelinase D. Spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis Loxosceles intermedia choline + ceramide 1-phosphate
-
 ?
sphingomyelin + H2O spingomyelinases D induces direct association of C1q to the erythrocyte membrane causing complement mediated autologous haemolysis Corynebacterium pseudotuberculosis choline + ceramide 1-phosphate
-
 ?
sphingomyelin + H2O
-
 Corynebacterium pseudotuberculosis ceramide-1-phosphate + choline
-
 ?
sphingomyelin + H2O
-
 Loxosceles intermedia ceramide-1-phosphate + choline
-
 ?

Synonyms

Synonyms Comment Organism
PLD
-
 Corynebacterium pseudotuberculosis
SMase D
-
 Corynebacterium pseudotuberculosis
SMase D
-
 Loxosceles intermedia
SMase P1
-
 Loxosceles intermedia
sphingomyelinase D
-
 Corynebacterium pseudotuberculosis
sphingomyelinase D
-
 Loxosceles intermedia