Cloned (Comment) | Organism |
---|---|
expression of EGFP-PLD1 in MIN6N8 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | dominant negative PLD1 inhibits glucose-induced Beta2 expression, and glucose-induced insulin secretion is blocked by treatment with 1-butanol or PLD1-siRNA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MIN6-N8 cell | - |
Homo sapiens | - |
pancreatic beta cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
phospholipase D1 | - |
Homo sapiens |
PLD1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | PLD1 expression is induced by high glucose levels | up |
General Information | Comment | Organism |
---|---|---|
metabolism | high glucose increases insulin secretion through a PLD1-related pathway, high glucose induces the PLD1 binding of Arf6, which is involved in the glucose-induced insulin secretion pathway | Homo sapiens |
physiological function | role of a phospholipase D-related signaling pathway in insulin secretion caused by high glucose in the pancreatic beta-cell line MIN6N8 | Homo sapiens |