Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Hg2+ | mercury chloride, and methylmercury, activates PLD, the stimulation is regulated by Ca2+ and calmodulin, mechanism, overview. Calcium chelating agents and calcium depletion, e.g. by EGTA, calmodulin inhibitors, e.g. calmidazolium chloride and trifluoperazine, and L-type calcium channel blockers nifedipine, nimodipine, and diltiazem attenuate the stimulation of PLD by mercury, overview | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular endothelial cell | from pulmonary artery | Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor | Bos taurus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLD | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Bos taurus |
General Information | Comment | Organism |
---|---|---|
physiological function | PLD generates bioactive lipid second messengers in vascular endothelial cells | Bos taurus |