Literature summary for 3.1.4.4 extracted from

Jacobs, A.C.; Hood, I.; Boyd, K.L.; Olson, P.D.; Morrison, J.M.; Carson, S.; Sayood, K.; Iwen, P.C.; Skaar, E.P.; Dunman, P.M.
Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis (2010), Infect. Immun., 78, 1952-1962.

Cloned(Commentary)

Cloned (Comment)	Organism
gene pld, DNA and amino acid sequence determination and analysis, A1S_2989 locus is predicted to encode a 368-amino-acid protein that contains two putative PLD active-site motifs, a perfect consensus motif spanning amino acid residues 15 to 30 and a nearly perfect match missing a single amino acid within the X6 region of the active-site motif spanning amino acid residues 265 to 279, gene locus A1S_2989 modulates phospholipase D activity	Acinetobacter baumannii

Cloned (Comment)

Organism

gene pld, DNA and amino acid sequence determination and analysis, A1S_2989 locus is predicted to encode a 368-amino-acid protein that contains two putative PLD active-site motifs, a perfect consensus motif spanning amino acid residues 15 to 30 and a nearly perfect match missing a single amino acid within the X6 region of the active-site motif spanning amino acid residues 265 to 279, gene locus A1S_2989 modulates phospholipase D activity

Acinetobacter baumannii

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of an Acinetobacter baumannii strain 98-37-09 transposon mutant library using the EZ-Tn5 R6Kori/KAN-2 Tnp transposome system, construction of the ACJ2, A1S_2989 mutant. Disruption of phospholipase D causes a reduction in the organism's ability to thrive in serum, a deficiency in epithelial cell invasion, and diminished pathogenesis in a murine model of pneumonia	Acinetobacter baumannii

Organism

Organism	UniProt	Comment	Textmining
Acinetobacter baumannii	-	strain ATCC 19606	-

Synonyms

Synonyms	Comment	Organism
PLD	-	Acinetobacter baumannii

General Information

General Information	Comment	Organism
malfunction	disruption of phospholipase D causes a reduction in the organism's ability to thrive in serum, a deficiency in epithelial cell invasion, and diminished pathogenesis in a murine model of pneumonia	Acinetobacter baumannii

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Release 2023.1 (January 2023)