Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-butanol | treatment of human neutrophils to butan-1-ol significantly dampenes functional responses such as degranualtion, chemotaxis, and oxidative burst | Homo sapiens | |
1-butanol | - |
Mus musculus | |
resveratrol | a phytoalexin with antiinflammatory activity in C5 anaphylatoxin-stimulated primary neutrophils, blocks PLD activity and membrane recruitment | Homo sapiens | |
resveratrol | a phytoalexin with antiinflammatory activity in C5 anaphylatoxin-stimulated primary neutrophils and in a mouse model of acute peritonitis, blocks PLD activity and membrane recruitment | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | translocation of OLD to the plasma membrane | Mus musculus | 5886 | - |
plasma membrane | translocation of OLD to the plasma membrane | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
male BALB/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
neutrophil | C5 anaphylatoxin-stimulated primary neutrophils | Mus musculus | - |
neutrophil | C5 anaphylatoxin-stimulated primary neutrophils | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PLD | - |
Mus musculus |
PLD | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Mus musculus |
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | pretreatment of human neutrophils with PLD inhibitor resveratrol significantly blocks oxidative burst, leukocyte migration, degranulation, and inflammatory cytokine production involving inhibition of sphingosine kinase activity and ERK1/2 phosphorylation | Homo sapiens |
malfunction | pretreatment of mouse neutrophils with PLD inhibitor resveratrol significantly blocks oxidative burst, leukocyte migration, degranulation, and inflammatory cytokine production involving inhibition of sphingosine kinase activity and ERK1/2 phosphorylation | Mus musculus |