Literature summary for 3.1.4.4 extracted from

Kang, D.W.; Lee, J.Y.; Oh, D.H.; Park, S.Y.; Woo, T.M.; Kim, M.K.; Park, M.H.; Jang, Y.H.; Min, d.o..S.
Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells (2009), Exp. Mol. Med., 41, 678-685.

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Cloned(Commentary)

Cloned (Comment)	Organism
transient expression of isozymes PLD1 or PLD2 in MDA-MB-231 cells and various other cancer cell lines, overview. MDA-MB-231 breast cancer cells express predominantly PLD1 protein. Expression of PLD isozymes is downregulated by triptolide at both transcriptional and post-transcriptional levels, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
phosphatidylcholine + H2O	Homo sapiens	-	choline + phosphatidic acid	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes PLD1 and PLD2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MDA-MB-231 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylcholine + H2O	-	Homo sapiens	choline + phosphatidic acid	-	?

Synonyms

Synonyms	Comment	Organism
PLD	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	triptolide, a natural, biologically active compound as a diterpenoid triepoxide originally purified from the Chinese herb Tripterygium wilfordii, induces suppression of phospholipase D expression, inhibits proliferation of MDA-MB-231 breast cancer cells and significantly inhibits PLD promoter activity in cells expressing the PLD promoters both PLD isozymes with similar inhibitory potency, triptolide decreases both basal and phorbol 12-myristate 13-acetate-induced PLD activation, overview	down
Homo sapiens	phorbol 12-myristate 13-acetate, PMA, as a tumor promoter enhances PLD1 expression via NFkappaB-dependent signaling pathway and increases cell proliferation and invasion	up

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Release 2023.1 (January 2023)