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Literature summary for 3.1.4.4 extracted from
- Phospholipase D in brain function and Alzheimer's disease (2010), Biochim. Biophys. Acta, 1801, 799-805.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | PLD localization, overview | Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | Homo sapiens | - |
choline + phosphatidic acid | phosphatidic acid has unique bioactive properties and can modify both the physical and signalling properties of lipid bilayers. Perturbation of phosphatidic metabolism can alter membrane dynamics with consequences on cell viability, phosphatidic acid functions, overview | ? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes PLD1 and PLD2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | - |
? | |
| phosphatidylcholine + H2O | - |
Homo sapiens | choline + phosphatidic acid | phosphatidic acid has unique bioactive properties and can modify both the physical and signalling properties of lipid bilayers. Perturbation of phosphatidic metabolism can alter membrane dynamics with consequences on cell viability, phosphatidic acid functions, overview | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | PLD structure, overview | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLD1 | - |
Homo sapiens |
| PLD2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | phospholipase D, a phosphatidic acid-synthesizing enzyme, is linked to multiple aspects of normal brain function and to Alzheimer's disease, the most common neurodegenerative disorder, an imbalance in phospholipids is involved in development of Alzheimer's disease, overview | Homo sapiens |
| physiological function | PLD is especially involved in regulating biosynthesis and metabolism of phospholipids. Role of phospholipase D in amyloid-beta protein precursor, APP, trafficking, amyloid-beta protein generation, and in signaling mechanisms downstream of beta-amyloid as well as in the trafficking and processing of amyloid precursor protein. PLD1 positively regulates the delivery of PS1 to the cell surface in an APP-independent fashion. Role of the PLD pathway in brain regulation, PLD function, overview | Homo sapiens |
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