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Literature summary for 3.1.4.4 extracted from

  • Taves, J.; Rastedt, D.; Canine, J.; Mork, D.; Wallert, M.A.; Provost, J.J.
    Sodium hydrogen exchanger and phospholipase D are required for alpha1-adrenergic receptor stimulation of metalloproteinase-9 and cellular invasion in CCL39 fibroblasts (2008), Arch. Biochem. Biophys., 477, 60-66.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
phenylephrine increases phosphatidylbutanol formation in CCL39 cells Cricetulus griseus
phosphatidylethanolamine activates PLD activity, leading to increased matrix metalloproteinase 9, MMP-9, activity Cricetulus griseus

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition of PLD significantly reduces the cell motility of CCL39 cells Cricetulus griseus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphatidylcholine + H2O Cricetulus griseus
-
 choline + phosphatidic acid
-
 ?

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DEDE cell a lung fibroblast cell line Cricetulus griseus
-
fibroblast
-
 Cricetulus griseus
-
fibrosarcoma cell
-
 Cricetulus griseus
-
lung
-
 Cricetulus griseus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PLD is also active in a transphosphatidylation assay with substrate 1-butanol resulting in production of phosphatidylbutanol Cricetulus griseus ?
-
 ?
phosphatidylcholine + H2O
-
 Cricetulus griseus choline + phosphatidic acid
-
 ?

Synonyms

Synonyms Comment Organism
PLD
-
 Cricetulus griseus

General Information

General Information Comment Organism
physiological function PLD serves as a sigalling intermediate for activation of matrix metalloproteinase 9, MMP-9, that is critical in digesting the extracellular matrix and has a vital function in tumor metastasis and invasion, overview. PKC-dependent activation of MMP-9 in fibrosarcoma cells requires PLD activity Cricetulus griseus