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Literature summary for 3.1.4.4 extracted from
- Phospholipase D activity in human platelets is inhibited by protein kinase A, involving inhibition of phospholipase D1 translocation (2008), Platelets, 19, 300-307.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| prostaglandin E1 | causes a modest elevation of PLD activity in resting platelets. prostaglandin E1-induced PLD activity is increased by 25% in the presence of Ca2+. Maximal activity at 5 micromol prostaglandin E1 | Homo sapiens |  |
| thrombin | - |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| forskolin | inhibits the activating effect of thrombin. Translocation to the plasma membrane of PLD1, but not PLD2, is inhibited | Homo sapiens | |
| prostaglandin E1 | inhibits the activating effect of thrombin; inhibits the activating effect of thrombin. Translocation to the plasma membrane of PLD1 is inhibited but only at high concentration | Homo sapiens | |
| protein kinase A | inhibits the activating effect of thrombin. Translocation to the plasma membrane of PLD1, but not PLD2, is inhibited | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | translocation to the plasma membrane of PLD1, but not PLD2, is inhibited by forskolin and protein kinase A | Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O14939 | - |
- |
| Homo sapiens | Q13393 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood platelet | concentrated platelet-rich plasma is used | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + ethanol | - |
Homo sapiens | choline + phosphatidylethanol | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| phospholipase D1 | - |
Homo sapiens |
| phospholipase D2 | - |
Homo sapiens |
| PLD1 | - |
Homo sapiens |
| PLD2 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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