Cloned (Comment) | Organism |
---|---|
expression in HEK-293 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | deletion of the phox homology domain in isoforms PLD1 or PLD2 results in reduction in activation of GTPase, mutants are unable to increase endocytosis of epidermal growth factor receptor. Silencing of enzymes expression retard endocytosis of epidermal growth factor | Homo sapiens |
R128K | isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor | Homo sapiens |
R145K | isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor | Homo sapiens |
R165K | isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor | Homo sapiens |
R197K | isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | phospholipase D functions as a GTPase activating protein through the phox homology domain, which directly activates the GTPase domain of dynamin. Enzyme increases epidermal growth factor receptor endocytosis at physiological concentrations of epidermal growth factor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | phospholipase D functions as a GTPase activating protein through the phox homology domain, which directly activates the GTPase domain of dynamin. Enzyme increases epidermal growth factor receptor endocytosis at physiological concentrations of epidermal growth factor | Homo sapiens | ? | - |
? |