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Literature summary for 3.1.4.4 extracted from

  • Lee, C.S.; Kim, I.S.; Park, J.B.; Lee, M.N.; Lee, H.Y.; Suh, P.G.; Ryu, S.H.
    The phox homology domain of phospholipase D activates dynamin GTPase activity and accelerates EGFR endocytosis (2006), Nat. Cell Biol., 8, 477-484.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information deletion of the phox homology domain in isoforms PLD1 or PLD2 results in reduction in activation of GTPase, mutants are unable to increase endocytosis of epidermal growth factor receptor. Silencing of enzymes expression retard endocytosis of epidermal growth factor Homo sapiens
R128K isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor Homo sapiens
R145K isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor Homo sapiens
R165K isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor Homo sapiens
R197K isoform PLD1, mutation in phox homology domain, reduction in activation of GTPase, unable to increase endocytosis of epidermal growth factor receptor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens phospholipase D functions as a GTPase activating protein through the phox homology domain, which directly activates the GTPase domain of dynamin. Enzyme increases epidermal growth factor receptor endocytosis at physiological concentrations of epidermal growth factor ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phospholipase D functions as a GTPase activating protein through the phox homology domain, which directly activates the GTPase domain of dynamin. Enzyme increases epidermal growth factor receptor endocytosis at physiological concentrations of epidermal growth factor Homo sapiens ?
-
?