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Literature summary for 3.1.4.4 extracted from

  • Koch, T.; Wu, D.F.; Yang, L.Q.; Brandenburg, L.O.; Hoellt, V.
    Role of phospholipase D2 in the agonist-induced and constitutive endocytosis of G-protein coupled receptors (2006), J. Neurochem., 97, 365-372.
    View publication on PubMed
Search for more literature for 3.1.4.4

Activating Compound

Activating Compound Comment Organism Structure
(D-Ala2, methyl-Phe4, Glyol5)enkephalin treatment of cells co-expressing isoform PLD2 and my-opioid receptor MOR1 leads to increase in PLD2 activity and an induction of receptor endocytosis Homo sapiens
my-opioid receptor variant MOR1D activation of isoform PLD2 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
K758R catalytically inactive. Inhibition of enzyme activity by overexpression of the mutant blocks the constitutive isoform PLD2 activation and impairs the endocytosis of my-opioid receptors MOR1D Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens endocytotic trafficking of my-opioid receptor MOR1, delta-opioid receptor DOR and cannabinoid receptor isoform CB1 are mediated by an isoform PLD2 dependent pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform PLD2
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information endocytotic trafficking of my-opioid receptor MOR1, delta-opioid receptor DOR and cannabinoid receptor isoform CB1 are mediated by an isoform PLD2 dependent pathway Homo sapiens ?
-
 ?