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Literature summary for 3.1.4.4 extracted from

  • Paruch, S.; Heinis, M.; Lemay, J.; Hoeffel, G.; Maranon, C.; Hosmalin, A.; Perianin, A.
    CCR5 signaling through phospholipase D involves p44/42 MAP-kinases and promotes HIV-1 LTR-directed gene expression (2007), FASEB J., 21, 4038-4046.
    View publication on PubMed
Search for more literature for 3.1.4.4

Application

Application Comment Organism
medicine enzyme is activated downstream of ERK1/2 kinases upon chemokine receptor CCR5 activation and plays a major role in promoting HIV-1 LTR transactivation and virus replication Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information expression of wild-type and catalytically inactive enzyme isoforms in HeLa-MAGI cells enhances and inhibits the LTR activation, respectively, without altering Tat expression. Wild-type and inactive enzyme isoforms also respectively potentiate and inhibit HIV-1BAL replication in MAGI cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is activated downstream of ERK1/2 kinases upon chemokine receptor CCR5 activation and plays a major role in promoting HIV-1 LTR transactivation and virus replication ?
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HeLa-MAGI cell activation of chemokine receptor CCR5 by MIP-1beta triggers a rapid and substantial enzyme activity. Triggering requires activity of ERK1/2-MAP-kinases and involves both isoforms PLD1 and PLD2 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is activated downstream of ERK1/2 kinases upon chemokine receptor CCR5 activation and plays a major role in promoting HIV-1 LTR transactivation and virus replication Homo sapiens ?
-
 ?