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Literature summary for 3.1.4.4 extracted from

  • Lehman, N.; Di Fulvio, M.; McCray, N.; Campos, I.; Tabatabaian, F.; Gomez-Cambronero, J.
    Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2 (2006), Blood, 108, 3564-3572.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.4

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in HL-60 cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information silencing of isoform PLD1 by siRNA leads to an abolishment of basal chemokinesis of HL-60 cells that cannot be rescued with chemoattractants ENA-78, FMLP, and IL-8. Transient overexpression of PLD1 increases both chemokinesis and chemotaxis toward IL-8 and FMLP but not toward ENA-78. Chemokinesis is not mediated by the enzymatic activity of PLD1, but the chemotactic response is Homo sapiens
additional information silencing of isoform PLD2 by siRNA leads to cell migration arrest, whereas ENA-78 selectively increases endogenous PLD2 activity and chemotaxis of HL-60 cells overexpressing enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isoform PLD1 isassociated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 ?
-
 ?
additional information Homo sapiens isoform PLD2 is associated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isoform PLD2
-
Homo sapiens Q13393 isoform PLD1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isoform PLD1 isassociated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 Homo sapiens ?
-
 ?
additional information isoform PLD2 is associated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 Homo sapiens ?
-
 ?