Cloned (Comment) | Organism |
---|---|
overexpression in HL-60 cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | silencing of isoform PLD1 by siRNA leads to an abolishment of basal chemokinesis of HL-60 cells that cannot be rescued with chemoattractants ENA-78, FMLP, and IL-8. Transient overexpression of PLD1 increases both chemokinesis and chemotaxis toward IL-8 and FMLP but not toward ENA-78. Chemokinesis is not mediated by the enzymatic activity of PLD1, but the chemotactic response is | Homo sapiens |
additional information | silencing of isoform PLD2 by siRNA leads to cell migration arrest, whereas ENA-78 selectively increases endogenous PLD2 activity and chemotaxis of HL-60 cells overexpressing enzyme | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | isoform PLD1 isassociated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 | ? | - |
? | |
additional information | Homo sapiens | isoform PLD2 is associated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isoform PLD2 | - |
Homo sapiens | Q13393 | isoform PLD1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isoform PLD1 isassociated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 | Homo sapiens | ? | - |
? | |
additional information | isoform PLD2 is associated with cell polarity and directionality concomitantly with adhesion and F-actin polymerization in response to IL-8 | Homo sapiens | ? | - |
? |