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Literature summary for 3.1.4.4 extracted from
- An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells (2005), J. Immunol., 174, 5201-5208.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | essential role for phospholipase D in activation of protein kinase C and degranulation in mast cells. Production of phosphatidic acid by PLD facilitates activation of protein kinase C and, in turn, degranulation, although additional PLD-dependent processes appear to be critical for antigen-mediated degranulation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| mast cell | transformed bone marrow-derived mast cell line | Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | essential role for phospholipase D in activation of protein kinase C and degranulation in mast cells. Production of phosphatidic acid by PLD facilitates activation of protein kinase C and, in turn, degranulation, although additional PLD-dependent processes appear to be critical for antigen-mediated degranulation | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PLD | - |
Mus musculus |
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Release 2023.1 (January 2023)
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