Literature summary for 3.1.4.4 extracted from

Chae, Y.C.; Lee, S.; Lee, H.Y.; Heo, K.; Kim, J.H.; Suh, P.G.; Ryu, S.H.
Inhibition of muscarinic receptor-linked phospholipase D activation by association with tubulin (2005), J. Biol. Chem., 280, 3723-3730.

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Inhibitors

Inhibitors	Comment	Organism	Structure
tubulin	increase in local membrane monomeric tubulin concentration inhibits PLD2 activity by direct interaction, carbachol increases the association between PLD2 with tubulin	Chlorocebus aethiops

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Chlorocebus aethiops	increase in local membrane monomeric tubulin concentration inhibits PLD2 activity. The PLD2 regulating mechanism via tubulin exists in endogeneous muscarinic receptor possessing cells	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Chlorocebus aethiops	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
COS-7 cell	-	Chlorocebus aethiops	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	increase in local membrane monomeric tubulin concentration inhibits PLD2 activity. The PLD2 regulating mechanism via tubulin exists in endogeneous muscarinic receptor possessing cells	Chlorocebus aethiops	?	-	?

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Release 2023.1 (January 2023)