Protein Variants | Comment | Organism |
---|---|---|
additional information | overexpression of isoforms PLD1 and PLD2, but not their inactive mutants, stimulates Co2+-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-butanol | inhibitor of enzyme. Pretreatment with 1-butanol suppresses Co2+-induced COX-2 expression and prostaglandin E2 formation | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | stimulation of enzyme activity and synthesis of COX-2 protein in time- and dose-dependent manner. Elevated expression of isoforms PLD1 and PLD2 increases hypoxia-induced COX-2 expression and prostaglandin E2 production. PLD1 enhances COX-2 expression by Co2+ via reactive oxygen species, p38 MAK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhances Co2+-induced COX-2 expression via reactive oxygen species and p38 MAP kinase, but not PKC-delta, PKA and ERK | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | O14939 | - |
- |
Homo sapiens | Q13393 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
U-87MG cell | - |
Homo sapiens | - |
U-87MG cell | astroglioma cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | protein casein kinase II stimulates basal phospholipase D (PLD1 and PLD2) activity as well as PMA-induced phospholipase D activation in human U87 astroglioma cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLD1 | - |
Homo sapiens |
PLD2 | - |
Homo sapiens |