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Literature summary for 3.1.4.4 extracted from

  • Kuan, Y.H.; Lin, R.H.; Tsao, L.T.; Chen, Y.L.; Tzeng, C.C.; Wang, J.P.
    Inhibition of phospholipase D activation by CYL-26z in formyl peptide-stimulated neutrophils involves the blockade of RhoA activation (2005), Biochem. Pharmacol., 70, 901-910.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-[4-acridin-[9-ylamino]phenyl]-5-methyl-3-methylenedihydrofuran-2-one inhibits the formyl-Met-Leu-Phe-stimulated phospholipase D activity, mainly through the blockade of RhoA activation and degranulation Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus 5-[4-acridin-[9-ylamino]phenyl]-5-methyl-3-methylenedihydrofuran-2-one inhibits the formyl-Met-Leu-Phe-stimulated phospholipase D activity, mainly through the blockade of RhoA activation and degranulation ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-O-octadecyl-sn-glycero-3-phosphocholine + H2O
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Rattus norvegicus 1-O-octadecyl-sn-glycero-3-phosphatidate + choline
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?
additional information 5-[4-acridin-[9-ylamino]phenyl]-5-methyl-3-methylenedihydrofuran-2-one inhibits the formyl-Met-Leu-Phe-stimulated phospholipase D activity, mainly through the blockade of RhoA activation and degranulation Rattus norvegicus ?
-
?