Literature summary for 3.1.4.4 extracted from

Hodgkin, M.N.; Masson, M.R.; Powner, D.; Saqib, K.M.; Ponting, C.P.; Wakelam, M.J.O.
Phospholipase D regulation and localization is dependent upon a phosphatidylinositol 4,5-bisphosphate-specific PH domain (2000), Curr. Biol., 10, 43-46.

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Activating Compound

Activating Compound	Comment	Organism	Structure
phosphatidylinositol	-	Homo sapiens
phosphatidylinositol-3,4,5-trisphosphate	effective activator	Homo sapiens
phosphatidylinositol-3,4-diphosphate	very effective activator	Homo sapiens
phosphatidylinositol-3,5-diphosphate	effective activator	Homo sapiens
phosphatidylinositol-3-phosphate	effective activator	Homo sapiens
phosphatidylinositol-4,5-diphosphate	very effective activator	Homo sapiens
phosphatidylserine	-	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
F250S	dramatic reduction of enzyme activity	Homo sapiens
K228R	dramatic reduction of enzyme activity	Homo sapiens
additional information	deletion of pleckstrin homology domain, disruption of normal cellular localization, loss of enzyme activity	Homo sapiens
S230F	dramatic reduction of enzyme activity	Homo sapiens
W253C	almost complete loss of enzyme activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes PLD1, PLD2	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphatidylcholine + H2O	-	Homo sapiens	choline + phosphatidate	-	?

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Release 2023.1 (January 2023)