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Literature summary for 3.1.4.4 extracted from
- Molecular and biochemical properties and physiological roles of plant phospholipase D (1999), Biochim. Biophys. Acta, 1439, 151-166.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phosphatidylethanolamine | required for maximal activity of the beta and gamma-enzymes | Arabidopsis sp. |  |
| phosphatidylinositol 4,5-bisphosphate | - |
Rattus norvegicus | |
| phosphatidylinositol 4,5-bisphosphate | binding is modulated by Ca2+ | Arabidopsis sp. | |
| phosphatidylinositol 4,5-bisphosphate | only in vitro | Homo sapiens | |
| phosphatidylinositol phosphate | - |
Arabidopsis sp. | |
| phosphatidylinositol phosphate | only in vitro | Homo sapiens | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
- |
Ricinus communis |
- |
Brassica oleracea |
- |
Spuriopimpinella brachycarpa |
- |
Vigna unguiculata |
- |
Nicotiana tabacum |
| three distinct cDNAs for the enzyme: alpha, beta, gamma | Arabidopsis sp. |
| two distinct cDNAs for the enzyme: type 1, type 2 | Oryza sativa |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Rattus norvegicus | |
| Ca2+ | Ca2+ dependent and independent enzymes | Saccharomyces cerevisiae | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Zea mays | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Arabidopsis sp. | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Ricinus communis | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Brassica oleracea | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Oryza sativa | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Spuriopimpinella brachycarpa | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Vigna unguiculata | |
| Ca2+ | 20-100 mM required for maximal activity in plants | Nicotiana tabacum | |
| Ca2+ | micromolar levels for maximal activity | Mus musculus | |
| Ca2+ | micromolar levels for maximal activity | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phospholipid + H2O | Mus musculus | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Homo sapiens | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Rattus norvegicus | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Saccharomyces cerevisiae | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Zea mays | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Arabidopsis sp. | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Ricinus communis | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Brassica oleracea | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Oryza sativa | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Catharanthus roseus | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Spuriopimpinella brachycarpa | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Vigna unguiculata | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | Nicotiana tabacum | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis sp. | - |
- |
- |
| Brassica oleracea | - |
- |
- |
| Catharanthus roseus | - |
madagascar periwinkles | - |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Nicotiana tabacum | P93400 | tabacco | - |
| Oryza sativa | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Ricinus communis | - |
castor bean | - |
| Saccharomyces cerevisiae | - |
yeast | - |
| Spuriopimpinella brachycarpa | - |
- |
- |
| Vigna unguiculata | O04865 | cow pea | - |
| Zea mays | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| complete to homogeneity | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + H2O | - |
Mus musculus | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Homo sapiens | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Rattus norvegicus | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Saccharomyces cerevisiae | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Arabidopsis sp. | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Ricinus communis | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Brassica oleracea | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Oryza sativa | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Spuriopimpinella brachycarpa | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Vigna unguiculata | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylcholine + H2O | - |
Nicotiana tabacum | 1,2-diacylglycerophosphate + choline | - |
? | |
| phosphatidylglycerol + H2O | - |
Arabidopsis sp. | glycerol + diacylglycerophosphate | - |
? | |
| phosphatidylglycerol + H2O | - |
Brassica oleracea | glycerol + diacylglycerophosphate | - |
? | |
| phosphatidylinositol + H2O | - |
Arabidopsis sp. | 1,2-diacylglycerophosphate + inositol | - |
? | |
| phosphatidylinositol + H2O | - |
Catharanthus roseus | 1,2-diacylglycerophosphate + inositol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Mus musculus | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Homo sapiens | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Rattus norvegicus | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Saccharomyces cerevisiae | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Zea mays | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Arabidopsis sp. | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Ricinus communis | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Brassica oleracea | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Oryza sativa | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Catharanthus roseus | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Spuriopimpinella brachycarpa | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Vigna unguiculata | phosphatidic acid + alcohol | - |
? | |
| phospholipid + H2O | phosphoric ester hydrolysis | Nicotiana tabacum | phosphatidic acid + alcohol | - |
? | |
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