Literature summary for 3.1.4.39 extracted from

Ohshima, N.; Kudo, T.; Yamashita, Y.; Mariggio, S.; Araki, M.; Honda, A.; Nagano, T.; Isaji, C.; Kato, N.; Corda, D.; Izumi, T.; Yanaka, N.
New members of the mammalian glycerophosphodiester phosphodiesterase family GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity (2015), J. Biol. Chem., 290, 4260-4271 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cell	Mus musculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.32	-	1-O-alkyl-sn-glycero-3-phosphocholine	pH 7.4, temperature not specified in the publication	Mus musculus
1	-	lysophosphatidylcholine	pH 7.4, temperature not specified in the publication	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9CRY7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
colon	-	Mus musculus	-
intestine	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-O-alkyl-sn-glycero-3-phosphocholine + H2O	i.e. lyso-platelet-activating factor	Mus musculus	1-O-alkyl-sn-glycerol 3-phosphate + choline	-	?
lysophosphatidylcholine + H2O	-	Mus musculus	lysophosphatidic acid + choline	-	?

Subunits

Subunits	Comment	Organism
?	x * 37000, SDS-PAGE	Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.032	-	lysophosphatidylcholine	pH 7.4, temperature not specified in the publication	Mus musculus
0.077	-	1-O-alkyl-sn-glycero-3-phosphocholine	pH 7.4, temperature not specified in the publication	Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.031	-	lysophosphatidylcholine	pH 7.4, temperature not specified in the publication	Mus musculus
0.24	-	1-O-alkyl-sn-glycero-3-phosphocholine	pH 7.4, temperature not specified in the publication	Mus musculus

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Release 2023.1 (January 2023)