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Literature summary for 3.1.4.39 extracted from

  • Tokumura, A.; Taira, S.; Kikuchi, M.; Tsutsumi, T.; Shimizu, Y.; Watsky, M.A.
    Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury (2012), Prostaglandins Other Lipid Mediat., 97, 83-89.
    View publication on PubMed
Search for more literature for 3.1.4.39

Inhibitors

Inhibitors Comment Organism Structure
Cu2+
-
 Oryctolagus cuniculus
EDTA
-
 Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activates Oryctolagus cuniculus
additional information no effect on enzyme activity by Ba2+, Mg2+, Ca2+, and Ni2+ Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-alkyl-sn-glycero-3-phosphocholine + H2O Oryctolagus cuniculus 16:0, 18:1 and 18:2-lysophosphatidylcholine are the predominant physiological substrates of the enzyme in rabbit aqueous humor 1-alkyl-sn-glycerol 3-phosphate + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
ciliary body the enzyme is constitutively released from corneal tissues and/or ciliary body into the aqueous humor, with no injury-induced increase in release following freeze-wounding Oryctolagus cuniculus
-
ciliary epithelium
-
 Oryctolagus cuniculus
-
cornea corneal stromal cells and endothelial and epithelial cells, the enzyme is constitutively released from corneal tissues and/or ciliary body into the aqueous humor, with no injury-induced increase in release following freeze-wounding Oryctolagus cuniculus
-
corneal endothelium
-
 Oryctolagus cuniculus
-
corneal epithelium
-
 Oryctolagus cuniculus
-
eye
-
 Oryctolagus cuniculus
-
keratocyte
-
 Oryctolagus cuniculus
-
retina
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-alkyl-sn-glycero-3-phosphocholine + H2O
-
 Oryctolagus cuniculus 1-alkyl-sn-glycerol 3-phosphate + choline
-
 ?
1-alkyl-sn-glycero-3-phosphocholine + H2O 16:0, 18:1 and 18:2-lysophosphatidylcholine are the predominant physiological substrates of the enzyme in rabbit aqueous humor Oryctolagus cuniculus 1-alkyl-sn-glycerol 3-phosphate + choline
-
 ?
additional information the enzyme is active on 16:0, 18:1 and 18:2-lysophosphatidylcholine, it also hydrolyzes three lysophosphatidylcholine subclasses in the following order: 16:0-acyl-lysophosphatidylcholine > 16:0-alkyl-lysophosphatidylcholine > 16:0-rich alkenyl-lysophosphatidylcholine, substrate specificity, overview Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
lysophospholipase D
-
 Oryctolagus cuniculus
lysoPLD
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Oryctolagus cuniculus

Expression

Organism Comment Expression
Oryctolagus cuniculus no injury-induced increase in release following freeze-wounding additional information

General Information

General Information Comment Organism
physiological function the enzyme is constitutively released from corneal tissues and/or ciliary body into the aqueous humor, with no injury-induced increase in release following freeze-wounding. Wound-induced increases in lysophosphatidic acid-like biological activity are due to linoleoyl species-rich molecular composition in aqueous humor from wounded eyes, possible mechanisms, overview Oryctolagus cuniculus