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Literature summary for 3.1.4.39 extracted from
- Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration (2013), Lab. Invest., 93, 508-519.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| real-time quantitative PCR expression analysis | Mus musculus |
| real-time quantitative PCR expression analysis | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-bromo-3(s)-hydroxy-4-(palmitoyloxy) butylphosphonate | inhibitory in vitro and in vivo | Mus musculus |  |
| bithionol | inhibitory in vitro and in vivo | Homo sapiens | |
| bithionol | inhibitory in vitro and in vivo | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Mus musculus BALB/c | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood vessel | intestinal, colonic microvessels | Homo sapiens | - |
| blood vessel | intestinal, colonic microvessels, high endothelial venules-like vessels | Mus musculus | - |
| colon | - |
Mus musculus | - |
| colon | - |
Homo sapiens | - |
| endothelium | - |
Homo sapiens | - |
| intestine | - |
Mus musculus | - |
| intestine | - |
Homo sapiens | - |
| mucosa | - |
Mus musculus | - |
| mucosa | - |
Homo sapiens | - |
| vascular system | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATX | - |
Mus musculus |
| ATX | - |
Homo sapiens |
| autotaxin | - |
Mus musculus |
| autotaxin | - |
Homo sapiens |
| lysophospholipase D | - |
Mus musculus |
| lysophospholipase D | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | enhanced enzyme expression in the inflamed mucosa from Crohn's disease and ulcerative colitis patients, the enzyme expression is remarkably higher in the actively inflamed mucosa than in the quiescent mucosa in the same patient | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | ATX inhibitor bithionol remarkably decreases lymphocyte migration to the intestine and ameliorates both dextran sodium sulfate-induced colitis and CD4-induced ileocolitis, administration of bithionol or 1-bromo-3(s)-hydroxy-4-(palmitoyloxy) butylphosphonate significantly decreases transmigration of splenocytes through high-endothelial-like vessels induced by TNF-alpha | Mus musculus |
| physiological function | in a dextran sodium sulfate mouse model, the enzyme expression level is considerably higher in colonic mucosa of chronically developed colitis than in colonic mucosa of acute colitis. The enzyme is required for lymphocyte transmigration, but not for surface expression of b7-integrin and CD11beta on splenocytes that migrated through epithelial cells. The role of the ATX-LPA axis in leukocyte transendothelial migration through induced high endothelial venule-like vessels has no tropism for surface expression of adhesion molecules on leukocytes | Mus musculus |
| physiological function | the enzyme and its reaction product lysophosphatidic acid have a critical role in lymphocyte migration to secondary lymphoid organs, involvement of the enzyme in inflammatory bowel disease patients, the enzyme/lysophosphatidic acid has a role in the migration of lymphocytes to the inflamed intestine | Homo sapiens |
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Release 2023.1 (January 2023)
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