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Literature summary for 3.1.4.39 extracted from

  • Tsuboi, K.; Okamoto, Y.; Ikematsu, N.; Inoue, M.; Shimizu, Y.; Uyama, T.; Wang, J.; Deutsch, D.G.; Burns, M.P.; Ulloa, N.M.; Tokumura, A.; Ueda, N.
    Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways (2011), Biochim. Biophys. Acta, 1811, 565-577.
    View publication on PubMed
Search for more literature for 3.1.4.39

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of GDE1 in COS-7 cells Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
 Mus musculus
EDTA
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Mus musculus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview ?
-
 ?
additional information Mus musculus C57BL/6 brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Mus musculus 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 ?
1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
-
 Mus musculus C57BL/6 1-alkyl-sn-glycerol 3-phosphate + ethanolamine
-
 ?
additional information brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview Mus musculus ?
-
 ?
additional information brain homogenate forms N-palmitoylethanolamine, N-oleoylethanolamine, and anandamide from their corresponding lyso-N-acylphosphatidylethanolamines by a Mg2+-dependent lysophospholipase D, substrate specificity, overview Mus musculus C57BL/6 ?
-
 ?

Synonyms

Synonyms Comment Organism
GDE1
-
 Mus musculus
glycerophosphodiesterase
-
 Mus musculus
lysophospholipase D
-
 Mus musculus
lysoPLD
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

General Information

General Information Comment Organism
physiological function GDE1 has a weak activity to generate N-palmitoylethanolamine from its corresponding 1-alkenyl-2-hydroxy-glycero-3-phospho(N-acyl)ethanolamines, suggesting that this enzyme is at least in part responsible for the lysophospholipase D activity in mouse brain Mus musculus