Cloned (Comment) | Organism |
---|---|
functional overexpression of V5-tagged ATX and secretion into conditioned medium | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | autotaxin is secreted | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Homo sapiens | |
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
epithelial cell | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
autotaxin | - |
Homo sapiens |
lysoPLD | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | lipopolysaccharides challenge induces ATX expression and release into the medium | up |
General Information | Comment | Organism |
---|---|---|
malfunction | a recombinant ATX mutant, lacking lysoPLD activity, or heat-inactived ATX also induces lung epithelial cell migration | Homo sapiens |
additional information | extracelluar ATX binds to the LPA receptor and integrin beta4 complex on A-549 cell surface | Homo sapiens |
physiological function | secreted autotaxin, which exhibits lysophospholipase D activity, stimulates lung epithelial cell migration through lysophosphatidic acid generation-dependent and -independent pathways lung cell migration is a crucial step for re-epithelialization that in turn is essential for remodelling and repair after lung injury, overview. Extracellular ATX stimulates cell migration through G?i-coupled LPA receptors, cytoskeleton rearrangement, phosphorylation of PKC delta and cortactin at the leading edge of migrating cells. Cortactin regulates ATX-V5-induced cell migration | Homo sapiens |