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Literature summary for 3.1.4.39 extracted from
- Crystallization and preliminary X-ray crystallographic analysis of human autotaxin (2011), Acta Crystallogr. Sect. F, 67, 450-453.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | is an attractive target for cancer therapy | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| alpha isoform of ATX, overexpression of the His-tagged enzyme in Escherichia coli strain BL21 (DE3) | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| purified recombinant ATX alpha isoform, hanging-drop vapour diffusion method, X-ray diffraction structure determination and analysis at 3.0 A resolution | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular | - |
Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| proteolytic modification | ATX is synthesized as a preproenzyme and proteolytically processed, the mature protein is secreted | Homo sapiens |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant His-tagged ATX alpha isoform from Escherichia coli strain BL21 (DE3) by nickel affinity chromatography and gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| A-2058 cell | secrets the mature ATX | Homo sapiens | - |
| melanoma cell | secrets the mature ATX | Homo sapiens | - |
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | lysophospholipase D generates lysophosphatidic acid from lysophosphatidylcholine | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| autotaxin | - |
Homo sapiens |
| ectonucleotide pyrophosphatase/phosphodiesterase 2 | - |
Homo sapiens |
| ENPP2 | - |
Homo sapiens |
| lysophospholipase D | - |
Homo sapiens |
| NPP2 | - |
Homo sapiens |
| PD-Ialpha | - |
Homo sapiens |
| phosphodiesterase Ialpha | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ATX stimulates tumour-cell migration, angiogenesis and metastasis | Homo sapiens |
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Release 2023.1 (January 2023)
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