Cloned (Comment) | Organism |
---|---|
stable expression of ATX in HEK-293 cells with secretion of the recombinnat enzyme | Rattus norvegicus |
Crystallization (Comment) | Organism |
---|---|
purified recombinant ATX, hanging drop vapour diffusion method, usage of crystallization solution 0.1 M MIB buffer, pH 8, 25% w/v PEG 1500, or 0.1 M MIB buffer, pH 9, 25% w/v PEG 1500, or 0.2 M sodium citrate, 20% w/v PEG 3350, X-ray diffraction structure determination and analysis at 2.0-2.6 A resolution | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | the enzyme is secreted | Rattus norvegicus | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
100000 | - |
about | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q64610 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
recombinant ATX from HEK-293 cell culture supernatant | Rattus norvegicus |
Subunits | Comment | Organism |
---|---|---|
More | ATX is a multi-domain protein encompassing two N-terminal somatomedin B-like domains, a central catalytic phosphodiesterase domain and a C-terminal nuclease-like domain | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
ATX | - |
Rattus norvegicus |
autotaxin | - |
Rattus norvegicus |
ENPP2 | - |
Rattus norvegicus |
lysophospholipase D | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | autotaxin exhibits lysophospholipase D activity, hydrolyzing lysophosphatidylcholine to the signalling lipid lysophosphatidic acid | Rattus norvegicus |