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Literature summary for 3.1.4.39 extracted from

  • Hausmann, J.; Christodoulou, E.; Kasiem, M.; De Marco, V.; van Meeteren, L.A.; Moolenaar, W.H.; Axford, D.; Owen, R.L.; Evans, G.; Perrakis, A.
    Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein (2010), Acta Crystallogr. Sect. F, 66, 1130-1135.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
stable expression of ATX in HEK-293 cells with secretion of the recombinnat enzyme Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
purified recombinant ATX, hanging drop vapour diffusion method, usage of crystallization solution 0.1 M MIB buffer, pH 8, 25% w/v PEG 1500, or 0.1 M MIB buffer, pH 9, 25% w/v PEG 1500, or 0.2 M sodium citrate, 20% w/v PEG 3350, X-ray diffraction structure determination and analysis at 2.0-2.6 A resolution Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Rattus norvegicus
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-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
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about Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q64610
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
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Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
recombinant ATX from HEK-293 cell culture supernatant Rattus norvegicus

Subunits

Subunits Comment Organism
More ATX is a multi-domain protein encompassing two N-terminal somatomedin B-like domains, a central catalytic phosphodiesterase domain and a C-terminal nuclease-like domain Rattus norvegicus

Synonyms

Synonyms Comment Organism
ATX
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Rattus norvegicus
autotaxin
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Rattus norvegicus
ENPP2
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Rattus norvegicus
lysophospholipase D
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Rattus norvegicus

General Information

General Information Comment Organism
physiological function autotaxin exhibits lysophospholipase D activity, hydrolyzing lysophosphatidylcholine to the signalling lipid lysophosphatidic acid Rattus norvegicus