Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
lysophosphatidylcholine + H2O | Mus musculus | - |
lysophosphatidic acid + choline | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FS-3 + H2O | - |
Mus musculus | ? | - |
? | |
lysophosphatidylcholine + H2O | - |
Mus musculus | lysophosphatidic acid + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATX | - |
Mus musculus |
autotaxin | - |
Mus musculus |
ENPP2 | - |
Mus musculus |
lysophospholipase D | - |
Mus musculus |
lysoPLD | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | E9.5 ATX null mutants exhibit a failure of neural tube closure, most likely independent of the circulatory failure, which correlates with decreased cell proliferation and increased cell death, obligatory deletion results to embryonic lethality most likely due to aberrant vascular branching morphogenesis and chorio-allantoic fusion | Mus musculus |
physiological function | ATX expression and lysophosphatidic acid signalling are vital for the development of the nervous system, ATX and lysophosphatidic acid are necessary for embryonic HIF-1a expression | Mus musculus |