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Literature summary for 3.1.4.39 extracted from
- ATX-LPA receptor axis in inflammation and cancer (2009), Cell Cycle, 8, 3695-3701.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the autotaxin-lysophosphatidic acid receptor axis is a rich therapeutic target in cancer | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Mus musculus | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lysophosphatidylcholine + H2O | Homo sapiens | - |
lysophosphatidic acid + choline | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| lysophosphatidylcholine + H2O | - |
Homo sapiens | lysophosphatidic acid + choline | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ATX | - |
Homo sapiens |
| autotaxin | - |
Homo sapiens |
| lysoPLD | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the autotaxin-lysophosphatidic acid receptor axis plays a causal role in breast tumorigenesis and cancer-related inflammation | Homo sapiens |
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Release 2023.1 (January 2023)
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