Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-methylenebis(4-chlorophenol) | - |
Homo sapiens | |
bithionol | - |
Homo sapiens | |
eosin Y | - |
Homo sapiens | |
H2L 5210574 | mixed-mode inhibition against ATX-mediated FS-3 hydrolysis | Homo sapiens | |
H2L 5564949 | mixed-mode inhibition against ATX-mediated FS-3 hydrolysis | Homo sapiens | |
H2L 5761473 | competitive ATX inhibitor | Homo sapiens | |
H2L 7839888 | mixed-mode inhibition against ATX-mediated FS-3 hydrolysis | Homo sapiens | |
H2L 7905958 | competitive inhibition with respect to ATX-mediated FS-3 hydrolysis and non-competitive inhibition with respect to ATX-mediated 4-nitrophenyl-TMP hydrolysis | Homo sapiens | |
H2L 7921385 | non-competitive inhibitor | Homo sapiens | |
Hexachlorophene | - |
Homo sapiens | |
L-histidine | - |
Homo sapiens | |
lysophosphatidic acid | efficacious inhibitor of ATX activity | Homo sapiens | |
merbromin | - |
Homo sapiens | |
NSC10881 | - |
Homo sapiens | |
NSC13792 | - |
Homo sapiens | |
NSC48300 | - |
Homo sapiens | |
NSC60016 | - |
Homo sapiens | |
NSC78785 | - |
Homo sapiens | |
NSC86629 | - |
Homo sapiens | |
RJC 03297 | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0037 | - |
FS-3 | - |
Homo sapiens | |
5.6 | - |
4-nitrophenyl-TMP | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl-TMP + H2O | - |
Homo sapiens | ? | - |
? | |
FS-3 + H2O | fluorogenic lysoPLD substrate | Homo sapiens | 2-(6-hydroxy-3-oxo-9a,10a-dihydro-3H-xanthen-9-yl)-5-[(18-hydroxy-15-oxo-3,6,9,12-tetraoxa-16-azaoctadec-1-yl)carbamoyl]benzoic acid + (2R)-2-hydroxy-3-(phosphonooxy)propyl 6-[(4-[(E)-[4-(dimethylamino)phenyl]diazenyl]benzoyl)amino]hexanoate | - |
? | |
lysophosphatidylcholine + H2O | - |
Homo sapiens | lysophosphatidic acid + choline | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATX | - |
Homo sapiens |
autotaxin | - |
Homo sapiens |
NPP2 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0019 | - |
H2L 7905958 | with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | |
0.002 | - |
H2L 5761473 | with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | |
0.0027 | - |
H2L 7839888 | with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | |
0.0065 | - |
H2L 7905958 | with respect to ATX-mediated 4-nitrophenyl-TMP hydrolysis | Homo sapiens | |
0.0093 | - |
H2L 7921385 | with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | |
0.0151 | - |
H2L 5564949 | with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0012 | - |
with respect to ATX-mediated 4-nitrophenyl-TMP hydrolysis | Homo sapiens | H2L 7905958 | |
0.0015 | - |
with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | H2L 7839888 | |
0.0016 | - |
with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | H2L 7905958 | |
0.0016 | - |
with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | H2L 7921385 | |
0.0017 | - |
with respect to ATX-mediated 4-nitrophenyl-TMP hydrolysis | Homo sapiens | H2L 7839888 | |
0.0068 | - |
with respect to ATX-mediated 4-nitrophenyl-TMP hydrolysis | Homo sapiens | H2L 5210574 | |
0.0068 | - |
with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | H2L 5210574 | |
0.0128 | - |
with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | H2L 5761473 | |
0.0128 | - |
with respect to ATX-mediated FS-3 hydrolysis | Homo sapiens | H2L 5564949 |