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Literature summary for 3.1.4.39 extracted from

  • Seifert, A.; Klonisch, T.; Wulfaenger, J.; Haag, F.; Dralle, H.; Langner, J.; Hoang-Vu, C.; Kehlen, A.
    The cellular localization of autotaxin impacts on its biological functions in human thyroid carcinoma cells (2008), Oncol. Rep., 19, 1485-1491.
    View publication on PubMed
Search for more literature for 3.1.4.39

Cloned(Commentary)

Cloned (Comment) Organism
transfection of FTC-238 cells with pEGFP-C3/ATX-construct for secretion of expressed ATX and with pD38tm/ATX-construct for production of membrane-anchored ATX respectively. sATX clones show higher cell motility than mATX clones (transwell filter assay), addition of interleukin-1beta to culture medium reduces cell motility due to downregulating ATX gene activity (mRNA expression level analysed by quantitative-RT-PCR), colony soft agar assay of sATX-clones results in bigger amount and bigger diameter of colonies compared to mATX-clones Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidylcholine + H2O Homo sapiens lysophospholipase D activity lysophosphatidic acid + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13822
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidylcholine + H2O lysophospholipase D activity Homo sapiens lysophosphatidic acid + choline
-
 ?

Synonyms

Synonyms Comment Organism
ATX
-
 Homo sapiens
autotaxin
-
 Homo sapiens
lysophospholipase D
-
 Homo sapiens
NPP2
-
 Homo sapiens
nucleotide phosphodiesterase/pyrophosphatase (NPP)
-
 Homo sapiens