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Literature summary for 3.1.4.39 extracted from

  • Kanda, H.; Newton, R.; Klein, R.; Morita, Y.; Gunn, M.D.; Rosen, S.D.
    Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs (2008), Nat. Immunol., 9, 415-423.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.4.39

Cloned(Commentary)

Cloned (Comment) Organism
isolation of cDNA encoding ATX from HEC cDNA library and transfection of COS-7 African green monkey kidney cells, recombinant expression and purification and immunoblot analysis for showing that HECs synthesize and secrete ATX Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
110000
-
 from HEC cells (isolation from mouse lymph nodes using immunomagnetic beads coupled to antibody MECA-79), SDS-PAGE, immunoblot Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lysophosphatidylcholine + H2O Mus musculus
-
 lysophosphatidic acid + choline
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein
-
 Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
high endothelial venule
-
 Mus musculus
-
lymph node
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lysophosphatidylcholine + H2O
-
 Mus musculus lysophosphatidic acid + choline
-
 ?

Synonyms

Synonyms Comment Organism
autotaxin (ATX)
-
 Mus musculus